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Published on: June 15, 2018
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Endothelial microRNAs and long noncoding RNAs in cardiovascular ageing
Diewertje I Bink1, Jessica Pauli2, Lars Maegdefessel3
1Department of Physiology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Cardiovascular Sciences, Microcirculation, Amsterdam, the Netherlands.
Atherosclerosis
|April 14, 2023
Summary
Aging promotes atherosclerosis by affecting endothelial cells. Specific non-coding RNAs (microRNAs and long non-coding RNAs) are key players in endothelial cell aging and senescence, offering potential therapeutic targets to combat age-related cardiovascular disease.
Area of Science:
- Cardiovascular Biology
- Molecular Biology
- Aging Research
Background:
- Cardiovascular diseases, including atherosclerosis, exhibit age-dependent progression.
- Endothelial cells are crucial in vascular health and atherosclerosis development.
- Non-coding RNAs, such as microRNAs and long non-coding RNAs, significantly influence endothelial function.
Purpose of the Study:
- To review microRNAs and long non-coding RNAs involved in endothelial aging.
- To discuss the role of these non-coding RNAs in endothelial cell function and senescence.
- To explore the potential of targeting non-coding RNAs for attenuating atherosclerosis.
Main Methods:
- Literature review and synthesis of existing research on non-coding RNAs and endothelial aging.
- Analysis of altered non-coding RNA expression patterns in aging endothelial cells.
- Discussion of the functional impact of these non-coding RNAs on endothelial senescence.
Main Results:
- Several microRNAs and long non-coding RNAs show altered expression during endothelial aging.
- These non-coding RNAs critically regulate endothelial cell function and senescence.
- Dysregulation of these non-coding RNAs contributes to age-related atherosclerosis.
Conclusions:
- Endothelial aging is modulated by specific non-coding RNAs.
- Targeting these non-coding RNAs presents a promising strategy for mitigating atherosclerosis.
- Understanding non-coding RNA roles in endothelial senescence is vital for cardiovascular health in aging populations.
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