Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does dihydroergotamine reduce plasma volume?

D Bergqvist, B Lindblad

    Acta Pharmacologica Et Toxicologica
    |February 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Dihydroergotamine (DHE) reduces plasma volume by 10% in sheep, an effect sustained for 24 hours. This study confirms DHE

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Commentary on 'Impact of Shaggy Aorta in Patients with Abdominal Aortic Aneurysm Following Open or Endovascular Aneurysm Repair'.

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2016
    Same author

    Chimney Grafts in Aortic Stent Grafting: Hazardous or Useful Technique? Systematic Review of Current Data.

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2015
    Same author

    Commentary on: "White matter damage of the brain is associated with poor outcomes in vascular surgery patients with claudication: a pilot study".

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2014
    Same author

    Medical risk factor treatment in peripheral arterial disease. Need for further improvement.

    International angiology : a journal of the International Union of Angiology·2013
    Same author

    Residual beta cell function at diagnosis of type 1 diabetes in children and adolescents varies with gender and season.

    Diabetes/metabolism research and reviews·2012
    Same author

    Age-dependent variation of genotypes in MHC II transactivator gene (CIITA) in controls and association to type 1 diabetes.

    Genes and immunity·2012

    Area of Science:

    • Pharmacology
    • Physiology
    • Vascular Biology

    Background:

    • Previous research suggested dihydroergotamine (DHE) may reduce plasma volume.
    • The precise mechanisms and extent of this effect require further investigation.

    Purpose of the Study:

    • To quantitatively assess the impact of dihydroergotamine on plasma volume.
    • To investigate the physiological responses to DHE administration in animal models and postoperative patients.

    Main Methods:

    • Animal experiments in sheep (n=10) using radioactive labeling to measure red blood cell and plasma volumes.
    • Clinical study in postoperative patients (n=9) monitoring diuresis, antidiuretic hormone (ADH), and aldosterone levels during DHE infusion.

    Main Results:

    Related Experiment Videos

    • Dihydroergotamine administration resulted in a 10% decrease in plasma volume in sheep, persisting for 24 hours.
    • Red blood cell volume remained unchanged.
    • In patients, DHE increased diuresis without altering ADH or aldosterone levels.

    Conclusions:

    • The findings support earlier evidence of dihydroergotamine-induced plasma volume reduction.
    • DHE's primary action on vascular tone, particularly capacitance vessels, likely contributes to the observed plasma volume decrease.
    • Plasma volume reduction is an additional effect of dihydroergotamine.