Biodegradable Long-Acting Injectables: Platform Technology and Industrial Challenges
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Published on: October 20, 2020
Marieta Duvnjak1, Alessia Villois1, Farshad Ramazani2
1Technical Research and Development, Novartis Pharma AG, Basel, Switzerland.
Abstract:
Long-acting injectables have been used to benefit patients with chronic diseases. So far, several biodegradable long-acting platform technologies including drug-loaded polymeric microparticles, implants (preformed and in situ forming), oil-based solutions, and aqueous suspension have been established. In this chapter, we summarize all the marketed technology platforms and discuss their challenges regarding development including but not limited to controlling drug release, particle size, stability, sterilization, scale-up manufacturing, etc. Finally, we discuss important criteria to consider for the successful development of long-acting injectables.
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