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Related Concept Videos

Protein Folding01:25

Protein Folding

8.2K
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
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Related Experiment Video

Updated: Aug 2, 2025

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
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Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

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Advanced Formulation Approaches for Proteins.

Corinna S Schlosser1, Gareth R Williams2, Karolina Dziemidowicz1

  • 1UCL School of Pharmacy, University College London, London, UK.

Handbook of Experimental Pharmacology
|April 14, 2023
PubMed
Summary
This summary is machine-generated.

Developing therapeutic protein and peptide formulations presents stability and delivery challenges. This review explores formulation technologies and delivery routes to improve biologic products for patients.

Keywords:
BiologicFormulationPeptidePharmaceutical technologyProtein

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Area of Science:

  • Pharmaceutical Sciences
  • Biotechnology
  • Drug Delivery

Background:

  • Therapeutic proteins and peptides offer high potency and specificity but face formulation instability, aggregation, and degradation issues.
  • Current parenteral delivery of protein actives as solutions presents significant disadvantages in cost, accessibility, and patient experience.
  • Limited success in developing novel biologic delivery systems has resulted in few market-ready products.

Approach:

  • Reviewing challenges in biologic formulation development.
  • Discussing explored technologies to overcome these formulation hurdles.
  • Considering various potential delivery routes for protein-based therapeutics.

Key Points:

  • Protein and peptide therapeutics are highly desirable due to their potency and specificity.
  • Instability, aggregation, and degradation are major challenges in formulating these agents.
  • Parenteral delivery as solutions is common but has drawbacks.
  • Novel delivery systems are crucial for improving biologic product accessibility and patient experience.
  • Exploring diverse delivery routes is essential for advancing biologic formulations.

Conclusions:

  • Significant challenges remain in developing stable and patient-friendly formulations for therapeutic proteins and peptides.
  • Continued innovation in formulation technologies and delivery systems is necessary to expand the market presence of biologic products.
  • The future likely involves diverse delivery strategies to enhance the therapeutic potential and patient acceptance of biologics.