Related Experiment Video

Updated: Aug 2, 2025

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
05:55

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head

Published on: September 27, 2024

609

Glucocorticoid Receptor Polymorphisms and Avascular Osteonecrosis After Kidney Transplantation

Jalal Etemadi, Mohammad Reza Jafari Nakhjavani, Saber Sepehri

  • 1Kidney Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. sepide.zununi@gmail.com.

Iranian Journal of Kidney Diseases
|April 15, 2023
PubMed
Abstract

Insights

Glucocorticoid receptor (GR) gene variations do not appear to increase the risk of avascular necrosis (AVN) in kidney transplant recipients. Further research is recommended to confirm these findings regarding AVN incidence.

Area of Science:

  • Nephrology
  • Pharmacogenomics
  • Immunosuppression

Background:

  • Glucocorticoids (GCs) are vital immunosuppressants post-kidney transplant.
  • Avascular Necrosis (AVN) of the femoral head is a significant non-traumatic adverse effect of GCs.
  • Understanding genetic predispositions to GC-related side effects is crucial.

Purpose of the Study:

  • To investigate the association between glucocorticoid receptor (GR) gene polymorphisms and AVN risk in kidney transplant recipients.
  • To evaluate specific GR polymorphisms (N363S, BclI, ER22/23EK, A3669G) as potential risk factors for AVN.

Main Methods:

  • A cohort of 99 renal transplant recipients was analyzed.
  • Genotyping was performed for four key GR polymorphisms: N363S (rs6195), BclI (rs41423247), ER22/23EK (rs6189/rs6190), and A3669G (rs6198).
  • Correlations between these polymorphisms and the incidence of AVN were assessed.

Main Results:

  • No statistically significant association was found between any of the tested GR polymorphisms (GC-sensitive or GC-resistant) and the development of AVN (P > .05).
  • Medication profiles differed significantly between patients with and without AVN (P < .001), suggesting other factors influence AVN development.

Conclusions:

  • Glucocorticoid receptor gene polymorphisms do not appear to play a critical role in the susceptibility to AVN after kidney transplantation.
  • The findings suggest that factors other than GR genetics are more influential in AVN development post-transplant.
  • Further studies are warranted to validate these results and explore alternative risk factors for AVN.

More Related Videos

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

16.2K
Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis07:05

Mouse Model of Alloimmune-induced Vascular Rejection and Transplant Arteriosclerosis

Published on: May 17, 2015

8.5K

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
30
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
41
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
37
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
45
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
45
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
48