A disposable edoxaban sensor chip using carbon paste electrode grafted with molecularly imprinted polymer

Area of Science:

• Analytical Chemistry
• Biomedical Engineering
• Materials Science

Background:

• Direct oral anticoagulants (DOACs) like edoxaban are widely used anticoagulants.
• Therapeutic drug monitoring (TDM) is not routinely required for DOACs.
• However, measuring blood drug levels is crucial for emergency care decisions.

Purpose of the Study:

• To develop a disposable sensor chip for rapid detection of edoxaban in blood.
• To assess the feasibility of using such sensors in emergency settings.

Main Methods:

• Fabrication of a disposable sensor chip using molecularly imprinted polymers (MIPs) on graphite particles.
• Grafting edoxaban tosylate as a template and sodium p-styrene sulfonate as a functional monomer.
• Electrochemical detection of edoxaban concentration via voltammetry within 150 seconds.

Main Results:

• The sensor demonstrated a concentration-dependent current response to edoxaban.
• Edoxaban detection sensitivity was confirmed in bovine whole blood.
• The sensor showed potential for rapid edoxaban detection in blood samples.

Conclusions:

• A disposable sensor for rapid edoxaban detection was successfully developed.
• The sensor shows promise for application in emergency care scenarios.
• Further improvements in selectivity, reproducibility, and sensitivity are required for clinical utility.