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Mn-Si-based nanoparticles-enhanced inhibitory effect on tumor growth and metastasis in photo-immunotherapy
Xueping Yu1, Xiupeng Wang2, Atsushi Yamazaki1
1Graduate School of Creative Science and Engineering, Waseda University, 3-4-1 Shin-Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.
Abstract:
The anticancer effect of phototherapy has been limited by some factors, including the easy degradation of photo agents, the complex tumor microenvironment, and the limited immune activation capacity, which impedes its efficiency in inhibiting tumor growth and tumor metastasis. Herein, Mn-doped mesoporous silica nanoparticles were synthesized to load the photo agent of IR 780, which were further coated with Mn (IMM). Notably, the combination of IMM and an 808 nm laser irradiation simultaneously inhibited the growth of primary tumors and distant untreated tumors in a bilateral animal model, which could be attributed to the protection of IMM to IR 780, the regulation functions to the tumor microenvironment, as well as the enhanced immune activation capacity. This work highlighted an alternative strategy for enhancing the inhibitory effect on both tumor growth and tumor metastasis in the combinational anticancer therapy of phototherapy and immunotherapy (photo-immunotherapy).
Insights
This study developed Mn-doped nanoparticles loaded with IR 780 (IMM) to improve phototherapy. IMM enhanced immune response, inhibited primary and distant tumors, and reduced metastasis in a novel photo-immunotherapy approach.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cancer Therapy
Background:
- Phototherapy's anticancer efficacy is limited by photoagent degradation, the tumor microenvironment, and insufficient immune activation.
- These factors hinder effective inhibition of tumor growth and metastasis.
Purpose of the Study:
- To develop a novel nanoplatform for enhanced phototherapy and immunotherapy.
- To investigate the combined effect of IR 780-loaded nanoparticles and laser irradiation on primary and distant tumors.
Main Methods:
- Synthesis of Mn-doped mesoporous silica nanoparticles loaded with IR 780 and coated with Mn (IMM).
- Evaluation of IMM's protective effect on IR 780, its role in regulating the tumor microenvironment, and its immune activation capacity.
- Assessment of combined IMM and 808 nm laser irradiation in a bilateral animal model.
Main Results:
- IMM protected the photoagent IR 780 from degradation.
- The treatment effectively regulated the tumor microenvironment and enhanced immune activation.
- Simultaneous administration of IMM and laser irradiation inhibited both primary and distant tumor growth and metastasis.
Conclusions:
- This novel photo-immunotherapy strategy overcomes limitations of traditional phototherapy.
- IMM-based treatment offers a promising approach for enhancing the inhibition of tumor growth and metastasis.
