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Updated: Aug 2, 2025

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
Immunity to pathogenic fungi in the eye
Serena Abbondante1, Sixto M Leal2, Heather L Clark3
1Department of Ophthalmology, and Department of Physiology and Biophysics, University of California, Irvine, CA, USA.
Abstract:
Fusarium, Aspergillus and Candida are important fungal pathogens that cause visual impairment and blindness in the USA and worldwide. This review will summarize the epidemiology and clinical features of corneal infections and discuss the immune and inflammatory responses that play an important role in clinical disease. In addition, we describe fungal virulence factors that are required for survival in infected corneas, and the activities of neutrophils in fungal killing, tissue damage and cytokine production.
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