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Related Concept Videos

Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

7.3K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Related Experiment Video

Updated: Aug 2, 2025

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex
09:55

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

8.4K

Multimodal Wnt signalling in the mouse neocortex.

Fabio Da Silva1, Christof Niehrs2

  • 1Division of Molecular Embryology, DKFZ-ZMBH Alliance, Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany.

Cells & Development
|April 15, 2023
PubMed
Summary
This summary is machine-generated.

Wnt/STOP signaling drives neocortex development by promoting neural progenitor differentiation and regulating cell division. This clarifies the distinct roles of Wnt/STOP and Wnt/β-catenin in brain development.

Keywords:
LRP6MicrocephalyMitosisNeurogenesisWnt signalling

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Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Signaling

Background:

  • Neocortex development relies on cell signaling pathways like Wnt.
  • The precise role of Wnt signaling in neocortex development is debated, with conflicting evidence on its effect on neural progenitor self-renewal versus differentiation.
  • Wnt/STOP is a newly identified Wnt pathway branch that stabilizes proteins, impacting cell cycle progression.

Purpose of the Study:

  • To elucidate the specific role of Wnt/STOP signaling in neocortex development.
  • To differentiate the functions of Wnt/STOP and Wnt/β-catenin pathways in neural progenitor behavior.
  • To investigate Wnt/STOP's regulation of neurogenesis and cell division dynamics.

Main Methods:

  • Utilized data from Da Silva et al. (2021) focusing on Wnt/STOP signaling.
  • Analyzed the stabilization of neurogenic transcription factors Sox4 and Sox11 by Wnt/STOP.
  • Examined the regulation of asymmetric cell division and cell cycle dynamics in apical and basal progenitors.

Main Results:

  • Wnt/STOP signaling promotes neural progenitor differentiation by stabilizing Sox4 and Sox11.
  • Wnt/STOP regulates asymmetric cell division in apical progenitors and cell cycle dynamics in basal progenitors.
  • A division of labor is proposed: Wnt/STOP drives cortical neurogenesis, while Wnt/β-catenin primarily mediates self-renewal.

Conclusions:

  • Wnt/STOP is identified as the main driver of cortical neurogenesis.
  • Wnt/β-catenin is mainly responsible for neural progenitor self-renewal.
  • This study resolves a long-standing question regarding Wnt signaling's role in cortical neural progenitor regulation.