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Biomarkers for chemotherapy and drug resistance in the mismatch repair pathway

Liu Dong1, Haoqin Jiang1, Zhihua Kang2

  • 1Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, PR China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|April 15, 2023
PubMed

Insights

DNA mismatch repair (MMR) status is crucial for predicting cancer chemotherapy response. This review explores MMR genes as potential biomarkers for treatment outcomes, despite ongoing controversies regarding mechanisms.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer therapies increasingly target DNA repair mechanisms, with many inhibitors in development.
  • Identifying biomarkers is vital for patient selection and predicting chemotherapy response.
  • The DNA mismatch repair (MMR) pathway is linked to cancer susceptibility and development.

Purpose of the Study:

  • To provide a concise overview of MMR genes.
  • To focus on MMR as a potential biomarker for predicting chemotherapy response and resistance.
  • To summarize current literature on the role of MMR in cancer treatment outcomes.

Main Methods:

  • Literature review of current research on DNA mismatch repair (MMR) genes.
  • Analysis of the correlation between MMR status and chemotherapy outcomes.
  • Discussion of potential mechanisms and controversies surrounding MMR's role in cancer therapy.

Main Results:

  • The status of DNA mismatch repair (MMR) has been shown to influence chemotherapy outcomes.
  • MMR genes are being investigated as potential biomarkers for predicting treatment efficacy.
  • Contradictory findings and complex mechanisms necessitate further research.

Conclusions:

  • The DNA mismatch repair (MMR) pathway plays a significant role in cancer development and treatment response.
  • Further investigation into MMR mechanisms is required to resolve existing controversies and optimize its use as a biomarker.
  • Understanding MMR status can potentially improve patient stratification for cancer therapies targeting DNA repair.
Keywords:
BiomarkerChemotherapyDNA damageDNA mismatch repairResistance

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