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Related Experiment Video

Updated: Aug 2, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

Remdesivir.

Ahmed H Bakheit¹, Hany Darwish², Ibrahim A Darwish²

¹Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia; Department of Chemistry, Faculty of Science and Technology, Al-Neelain University, Khartoum, Sudan.

Profiles of Drug Substances, Excipients, and Related Methodology

|April 15, 2023

Summary

This summary is machine-generated.

Remdesivir (GS-5734) is a broad-spectrum antiviral prodrug. This review details its properties, analysis, and pharmacological effects, including its role in COVID-19 treatment.

Keywords:

(GS-5734)Antiviral drug COVID-19 Clinical pharmacology GS-441524 monophosphate HPLC, methods of preparation Remdesivir Spectrometric analysis

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Area of Science:

Pharmacology
Virology
Medicinal Chemistry

Background:

Remdesivir (GS-5734) is an antiviral agent initially developed for Hepatitis C.
It has been investigated for Ebola and Marburg virus infections and authorized for COVID-19 treatment in several countries.

Approach:

This chapter provides a comprehensive review of Remdesivir (GS-5734).
It covers nomenclature, physicochemical properties, preparation, and identification.
Includes qualitative and quantitative analytical techniques, ADME profiles, and pharmacological effects.

Key Points:

Remdesivir is a prodrug metabolized to an active ribonucleotide analogue inhibitor of viral RNA polymerase.
The review details various analytical methods, including chromatographic and spectroscopic techniques.
Focuses on the comprehensive characterization and application of Remdesivir.

Conclusions:

This review offers a detailed overview of Remdesivir's scientific and clinical profile.
It serves as a resource for understanding its multifaceted applications and analytical methodologies.