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Published on: June 6, 2017
The role of the nucleolus in regulating the cell cycle and the DNA damage response
Dharaniya Sakthivel1, Alexandra Brown-Suedel2, Lisa Bouchier-Hayes3
1Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States; Department of Pediatrics, Division of Hematology-Oncology, Baylor College of Medicine, Houston, TX, United States; Texas Children's Hospital William T Shearer Center for Human Immunobiology, Houston, TX, United States.
Abstract:
The nucleolus has long been perceived as the site for ribosome biogenesis, but numerous studies suggest that the nucleolus carefully sequesters crucial proteins involved in multiple cellular functions. Among these, the role of nucleolus in cell cycle regulation is the most evident. The nucleolus is the first responder of growth-related signals to mediate normal cell cycle progression. The nucleolus also senses different cellular stress insults by activating diverse pathways that arrest the cell cycle, promote DNA repair, or initiate apoptosis. Here, we review the emerging concepts on how the ribosomal and nonribosomal nucleolar proteins mediate such cellular effects.
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