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Updated: Aug 2, 2025
A Dual Tracer PET-MRI Protocol for the Quantitative Measure of Regional Brain Energy Substrates Uptake in the Rat
Published on: December 28, 2013
α-D-Glucose as a non-radioactive MRS tracer for metabolic studies of the brain
Guodong Weng1,2, Piotr Radojewski1,2, Johannes Slotboom3,4
1Institute for Diagnostic and Interventional Neuroradiology, Support Center for Advanced Neuroimaging (SCAN), Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.
Abstract:
Changes in brain glucose metabolism occur in many neurological disorders as well as during aging. Most studies on the uptake of glucose in the brain use positron emission tomography, which requires injection of a radioactive tracer. Our study shows that ultra-high-field 1H-MRS can be used to measure α-D-glucose at 5.22 ppm in vivo, and the α-D-glucose can be used as a radiation-free tracer in the human brain.
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