Recent advances in multimode microfluidic separation of particles and cells
Yongxin Song1, Deyu Li1, Xiangchun Xuan2
1College of Marine Engineering, Dalian Maritime University, Dalian, P. R. China.
Electrophoresis
|April 16, 2023
Summary
Multimode microfluidic separation integrates active and passive methods for enhanced particle and cell separation. This approach overcomes limitations of single-mode techniques, improving efficiency for complex samples in lab-on-a-chip systems.
Area of Science:
- Microfluidics
- Biotechnology
- Analytical Chemistry
Background:
- Microfluidic separation is vital for lab-on-a-chip devices across science, engineering, and industry.
- Current single-mode separation methods (active or passive) struggle with heterogeneous samples.
- Limitations include reduced effectiveness and specificity when dealing with complex real-world samples.
Purpose of the Study:
- To review recent advancements in multimode microfluidic particle and cell separation.
- To highlight the advantages of integrating multiple separation techniques.
- To discuss strategies for overcoming single-mode separation limitations.
Main Methods:
- Review of serial-mode prefocused separation techniques.
- Analysis of serial-mode multistage separation strategies.
- Examination of parallel-mode force-tuned separation approaches.
Main Results:
- Integrated multimode separations offer improved specificity, resolution, and throughput.
- Multimode approaches enhance the effectiveness of particle and cell separation from heterogeneous samples.
- Recent advances demonstrate successful implementation of serial and parallel multimode strategies.
Conclusions:
- Multimode microfluidic separation is a promising strategy for advanced lab-on-a-chip applications.
- Combining active and passive methods significantly boosts separation performance.
- This review provides insights into the latest developments in integrated microfluidic separation technologies.
