LIVE-Net: Comprehensive 3D vessel extraction framework in CT angiography

The extraction of vessels from computed tomography angiography (CTA) is significant in diagnosing and evaluating vascular diseases. However, due to the anatomical complexity, wide intensity distribution, and small volume proportion of vessels, vessel extraction is laborious and time-consuming, and it is easy to lead to error-prone diagnostic results in clinical practice. This study proposes a novel comprehensive vessel extraction framework, called the Local Iterative-based Vessel Extraction Network (LIVE-Net), to achieve 3D vessel segmentation while tracking vessel centerlines. LIVE-Net contains dual dataflow pathways that work alternately: an iterative tracking network and a local segmentation network. The former can generate the fine-grain direction and radius prediction of a vascular patch by using the attention-embedded atrous pyramid network (aAPN), and the latter can achieve 3D vascular lumen segmentation by constructing the multi-order self-attention U-shape network (MOSA-UNet). LIVE-Net is trained and evaluated on two datasets: the MICCAI 2008 Coronary Artery Tracking Challenge (CAT08) dataset and head and neck CTA dataset from the clinic. Experimental results of both tracking and segmentation show that our proposed LIVE-Net exhibits superior performance compared with other state-of-the-art (SOTA) networks. In the CAT08 dataset, the tracked centerlines have an average overlap of 95.2%, overlap until first error of 91.2%, overlap with the clinically relevant vessels of 98.3%, and error distance inside of 0.21 mm. The corresponding tracking overlap metrics in the head and neck CTA dataset are 96.7%, 91.0%, and 99.8%, respectively. In addition, the results of the consistent experiment also show strong clinical correspondence. For the segmentation of bilateral carotid and vertebral arteries, our method can not only achieve better accuracy with an average dice similarity coefficient (DSC) of 90.03%, Intersection over Union (IoU) of 81.97%, and 95% Hausdorff distance (95%HD) of 3.42 mm , but higher efficiency with an average time of 67.25 s , even three times faster compared to some methods applied in full field view. Both the tracking and segmentation results prove the potential clinical utility of our network.