Risk assessment of bisphenol A (BPA) in Irish meat and meat products

Bisphenol A (BPA) is a chemical with large-scale applications in the manufacturing of industrial products. Concerns have been raised regarding human exposure to BPA and dietary consumption is the main route of exposure. BPA is recognised as an endocrine disruptor with multiple adverse effects on the reproductive, immune, and nervous systems. This study aimed to conduct a probabilistic risk assessment to evaluate the human health risk based on the raw concentration data (N = 1266) of BPA in non-canned meat and meat products purchased from supermarkets and local butchers in Dublin and the surrounding area. The mean exposure levels for BPA in non-canned meat and meat products, fresh meat, and processed meat products among children were 0.019, 0.0022, and 0.015 μg (kg bw)^-1 day^-1, respectively. Therefore, simulated human exposures to BPA were far below the EFSA recommended current temporary tolerable daily intake (t-TDI) of 4 μg (kg bw)^-1 day^-1. However recently, the EFSA has proposed a draft TDI of 0.04 ng (kg bw)^-1 day^-1 to replace the current t-TDI. Hence, our results indicated potential health concerns as the estimated exposure levels (5th-95th percentile) were below current t-TDI but above draft TDIs. Further investigation into the source of BPA contamination in processed meat products is highly recommended. The research presented here will inform the public, meat producers and processors, and policymakers on potential exposure to BPA.