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Esophageal function in chronic alcoholics.

L S Silver, T M Worner, M A Korsten

    The American Journal of Gastroenterology
    |June 1, 1986
    PubMed
    Summary
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    Chronic alcohol ingestion alters esophageal function, including increased lower esophageal sphincter pressure. However, these changes, along with salivary alterations, do not fully explain the heightened risk of esophagitis in alcoholics.

    Area of Science:

    • Gastroenterology
    • Ethanol-induced esophagitis research
    • Esophageal motility and function

    Background:

    • Chronic ethanol ingestion is linked to esophagitis pathogenesis.
    • Esophageal motility and acid clearance may be altered by alcohol.
    • Understanding these alterations is crucial for managing alcoholic esophagitis.

    Purpose of the Study:

    • To investigate abnormalities in esophageal motility and acid clearance in chronic alcoholics.
    • To examine salivary output, acid-neutralizing capacity, and bicarbonate concentration in alcoholics.
    • To determine if observed esophageal and salivary alterations explain the increased esophagitis risk.

    Main Methods:

    • Esophageal manometry was performed.
    • Acid-clearance studies were conducted.

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  • Salivary output, acid-neutralizing capacity, and bicarbonate concentration were measured.

    • Main Results:

    • Increased lower esophageal sphincter pressure was observed, normalizing after ethanol withdrawal.
    • Tertiary contractions were more frequent, but other esophageal motility parameters were normal.
    • Salivary parameters (flow, acid-neutralizing capacity, bicarbonate) did not differ significantly from controls, but the correlation between bicarbonate and acid-neutralizing capacity was lost in alcoholics.

    Conclusions:

    • Chronic ethanol ingestion alters specific esophageal functions and salivary composition.
    • These alterations are unlikely to be the primary cause of increased esophagitis risk in alcoholics.
    • Further research may be needed to fully elucidate the mechanisms of alcoholic esophagitis.