Unbalanced 1;7 translocation and therapy-induced hematologic disorders: a possible relationship

Area of Science:

• Hematology
• Cytogenetics
• Oncology

Background:

• A specific chromosome abnormality, identified as +der(1),t(1;7)(p11;p11), was observed in bone marrow samples.
• This abnormality was noted in 12 patients diagnosed with various hematologic disorders between 1980 and 1984 at the Mayo Clinic.

Purpose of the Study:

• To investigate the potential relationship between the +der(1),t(1;7)(p11;p11) chromosome abnormality and hematologic disorders.
• To explore the possible association with treatment-induced hematologic conditions.

Main Methods:

• Cytogenetic evaluation of bone marrow samples from 12 patients.
• Review of patient histories, including previous therapies for malignant disorders.

Main Results:

• The +der(1),t(1;7)(p11;p11) abnormality was present in patients with myeloproliferative disorders, myelodysplastic syndromes, acute leukemia, and treated multiple myeloma.
• Seven of the 11 patients with available therapy information had a history of chemotherapy for a prior malignancy.

Conclusions:

• The study suggests a possible association between the +der(1),t(1;7)(p11;p11) chromosome abnormality and treatment-induced hematologic disorders.
• The observed chromosome abnormality may arise from a reciprocal chromatid translocation and adjacent I segregation within a quadriradial configuration.