Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

1.4K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An electronic equilibrium strategy to drive the design of reversible fluorescent probes for sulfur dioxide and formaldehyde.

Chemical science·2026
Same author

Temperature Gradient-Induced Microstructural Evolution and Wear Resistance Enhancement in High-Manganese Steels by Laser Transformation Hardening.

Materials (Basel, Switzerland)·2026
Same author

Giant and Actively Tunable Second-Harmonic Generation in Bilayer Graphene.

ACS nano·2026
Same author

The creation and verification of a detection model for mild cognitive impairment by employing eye-tracking and gait metrics.

Journal of Alzheimer's disease : JAD·2026
Same author

Carbon monoxide-triggered near-infrared photoacoustic-fluorescent integrated visualization tool for auxiliary diagnosis of heart failure and evaluation of reversal drug efficacy.

Smart molecules : open access·2026
Same author

Corrigendum to "Total saponins from Panax japonicus mediate the paracrine interaction between adipocytes and macrophages to promote lipolysis in the adipose tissue during aging via the NLRP3 inflammasome/GDF3/ATGL axis" [ Phytomedicine 136 (2025)/156304].

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026

Related Experiment Video

Updated: Aug 2, 2025

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
11:32

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Published on: January 3, 2025

1.0K

HMGB1, angel or devil, in ischemic stroke.

Bin Gao1, Shuwen Wang1, Jiangfeng Li2

  • 1Department of Neurology, Xi'an No. 3 Hospital, the Affiliated Hospital of Northest University, Xi'an, Shaanxi, P.R. China.

Brain and Behavior
|April 17, 2023
PubMed
Summary

High-mobility group box 1 protein (HMGB1) has dual roles in ischemic stroke, causing early damage and promoting late-stage repair. Its complex functions depend on modification, receptors, and stroke stage, requiring further investigation.

Keywords:
HMGB1atherosclerosisimmune tissue repairischemic strokepathological mechanism

More Related Videos

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

14.9K
A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

460

Related Experiment Videos

Last Updated: Aug 2, 2025

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
11:32

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Published on: January 3, 2025

1.0K
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

14.9K
A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

460

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pathology

Background:

  • High-mobility group box 1 protein (HMGB1) is implicated in ischemic stroke pathogenesis, brain injury, and repair.
  • Its precise role in ischemic stroke requires further elucidation.

Purpose of the Study:

  • To review the literature on HMGB1's structure, modifications, and functions in cerebral ischemia.
  • To clarify the complex roles of HMGB1 in different stages and subtypes of ischemic stroke.

Main Methods:

  • Comprehensive literature search and narrative review.
  • Analysis of HMGB1's basic structure, structural modification, and functional roles.

Main Results:

  • HMGB1 is crucial for cell death, immunity, inflammation, thrombosis, and tissue remodeling.
  • It contributes to early-stage ischemic injury and late-stage repair.
  • HMGB1 has neurotrophic effects in acute white matter stroke but is damaging in chronic ischemia.

Conclusions:

  • HMGB1's role in cerebral infarction is complex, influenced by modifications, receptors, and stroke characteristics.
  • Future research should focus on the spatiotemporal dynamics of HMGB1.
  • Integrating different stages and infarct subtypes is essential for future HMGB1 studies.