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TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application

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Published on: June 8, 2016

Bone adhesive materials: From bench to bedside.

Hatice B Bingol^1,2, Johan C M E Bender², Joost A Opsteen²

¹Department of Dentistry-Regenerative Biomaterials, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

Materials Today. Bio

|April 17, 2023

Summary

This summary is machine-generated.

Biodegradable bone adhesives aim to replace metal implants for bone fixation but face numerous challenges. This review examines their development, testing, and clinical potential.

Keywords:

Biomaterials Bone adhesive Bone fracture Bone glue Orthopedic surgery

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Area of Science:

Biomaterials Science
Orthopedic Surgery
Polymer Chemistry

Background:

Biodegradable bone adhesives are emerging biomaterials for bone fixation, offering an alternative to traditional metallic devices.
Current bone adhesives do not meet all necessary requirements for widespread clinical adoption.
Significant research is ongoing to develop advanced bone-bonding materials.

Purpose of the Study:

To provide a comprehensive review of biodegradable bone adhesives from a translational perspective.
To define, classify, and explore the chemistry of various bone adhesive types.
To critically assess adhesion testing methods and the preclinical/clinical applicability of bone adhesives.

Main Methods:

Literature review focusing on studies of bone adhesives with rapid setting times (minutes to days).
Analysis of definitions, classifications, and chemical properties of bone adhesives.
Critical evaluation of experimental adhesion tests and assessment of preclinical and clinical data.

Main Results:

Identified key requirements for successful bone adhesives.
Highlighted the limitations of current bone adhesive technologies.
Examined the translational gap between laboratory findings and clinical application.

Conclusions:

Biodegradable bone adhesives hold significant promise for bone fixation but require further development to meet all clinical demands.
Standardized and relevant adhesion testing is crucial for evaluating bone adhesive performance.
Continued research into material science and translational studies is essential for advancing bone adhesive technology.