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Antibiotic-associated interstitial nephritis and nephrotic syndrome
American Journal of Nephrology
|January 1, 1986
Summary
Antibiotics can cause kidney problems in children. An 8-month-old infant developed reversible interstitial nephritis and minimal-change nephrotic syndrome after antibiotic treatment, highlighting a rare but significant adverse drug reaction.
Area of Science:
- Pediatric Nephrology
- Clinical Pharmacology
- Adverse Drug Reactions
Background:
- Interstitial nephritis and minimal-change nephrotic syndrome are known side effects of nonsteroidal anti-inflammatory agents in adults.
- Recent case reports suggest these conditions may also be linked to ampicillin and rifampin in adults.
- The occurrence of this combination in pediatric patients remains less understood.