Magnetic resonance imaging reference values for cardiac morphology, function and tissue composition in adolescents
Carlos Real1,2, Rocío Párraga1,2, Gonzalo Pizarro1,3,4
1Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
Eclinicalmedicine
|April 17, 2023
Summary
This study established sex-specific cardiovascular magnetic resonance (CMR) reference values for adolescents. These findings aid in diagnosing cardiac conditions like cardiomyopathies and myocarditis in this age group.
Area of Science:
- Cardiology
- Medical Imaging
- Pediatric Health
Background:
- Cardiovascular magnetic resonance (CMR) is crucial for assessing cardiac anatomy, function, and tissue composition.
- Reference values for CMR in adolescents are limited, hindering accurate clinical interpretation.
- This study addresses the need for sex-specific CMR data in adolescents.
Purpose of the Study:
- To establish sex-specific cardiovascular magnetic resonance (CMR) reference values for biventricular and atrial dimensions and function in adolescents.
- To provide reference values for myocardial relaxation times in this population.
- To support clinical practice and differential diagnosis of cardiac diseases in adolescents.
Main Methods:
- A cross-sectional study involving 123 adolescents (aged 15-18 years) without known cardiovascular disease.
- Non-contrast 3-Tesla CMR scans were performed using cine steady-state free-precession, T2-GraSE, and native MOLLI T1-mapping sequences.
- Analysis focused on biventricular and atrial dimensions, function, and myocardial tissue characteristics.
Main Results:
- Boys exhibited significantly higher indexed left and right ventricular end-diastolic volumes and left ventricular mass compared to girls.
- Left ventricular ejection fraction did not differ significantly by sex; right ventricular ejection fraction trended lower in boys.
- Global myocardial native T1 relaxation time was lower in boys, while T2 relaxation time showed no significant sex difference. Sex-stratified percentile tables are provided.
Conclusions:
- This study provides comprehensive, sex-stratified CMR reference values for adolescent cardiac dimensions, function, and myocardial tissue properties.
- These reference values are valuable for clinical practice and the differential diagnosis of cardiac conditions in adolescents.
- The findings contribute to a better understanding of normal cardiac variations in adolescence.
Keywords:
AdolescentDifferential diagnosisMagnetic resonancePediatricsReference valuesVentricular functionMore Related Videos
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