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Perinatal events and cerebral palsy.

P A Hensleigh, T Fainstat, R Spencer

    American Journal of Obstetrics and Gynecology
    |May 1, 1986
    PubMed
    Summary

    Recent studies challenge the 1950s hypothesis that identical risk factors cause both cerebral palsy and perinatal mortality. Evidence indicates distinct pathways for these conditions, refuting the idea of shared causation at varying intensities.

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    Area of Science:

    • Neurology
    • Developmental Pediatrics
    • Public Health

    Background:

    • A long-standing hypothesis suggested shared risk factors for cerebral palsy (CP) and perinatal mortality.
    • This hypothesis proposed that factors causing death, if less severe, could lead to CP.
    • This theory originated in the 1950s and has influenced research for decades.

    Purpose of the Study:

    • To review and critically evaluate recent scientific evidence concerning the etiology of cerebral palsy.
    • To challenge and refute the outdated hypothesis of identical causal pathways for CP and perinatal mortality.
    • To present data that contradicts the notion of shared risk factors at different intensities.

    Main Methods:

    • Systematic review of recent epidemiological and etiological studies on cerebral palsy.
    • Analysis of data investigating risk factors for both cerebral palsy and perinatal mortality.
    • Critical appraisal of the validity of the 1950s hypothesis in light of current research.

    Main Results:

    • Multiple recent studies provide data inconsistent with the hypothesis.
    • Evidence suggests that the risk factors and pathways for cerebral palsy differ from those for perinatal mortality.
    • The intensity, frequency, or duration of risk factors do not uniformly link perinatal mortality causes to cerebral palsy.

    Conclusions:

    • The hypothesis that identical risk factors cause cerebral palsy and perinatal mortality is refuted by current evidence.
    • The etiological pathways for cerebral palsy and perinatal mortality are not the same.
    • Outdated theories should be reassessed in light of contemporary scientific findings.

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