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Effect of phenylephrine on accommodation.

J A Mordi, W M Lyle, G Y Mousa

American Journal of Optometry and Physiological Optics

|April 1, 1986

Summary

Phenylephrine hydrochloride impacts accommodation, suggesting sympathetic nervous system involvement. Anesthetics prolong phenylephrine

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Area of Science:

Ophthalmology
Neuroscience

Background:

The role of the sympathetic nervous system in visual accommodation is debated.
Phenylephrine hydrochloride is a sympathomimetic agent.

Purpose of the Study:

To investigate the effect of phenylephrine hydrochloride on accommodation.
To examine the influence of iris pigmentation and topical anesthetics on this effect.

Main Methods:

Topical instillation of phenylephrine hydrochloride.
Assessment of accommodation and pupil diameter.
Consideration of iris color and prior anesthetic application.

Main Results:

The sympathetic nervous system influences accommodation.
Phenylephrine hydrochloride affects accommodation and pupil diameter.
Topical anesthetics prolong the effects of phenylephrine, particularly in eyes with varying iris pigmentation.

Conclusions:

Sympathetic nervous system activation plays a role in visual accommodation.
Anesthetic premedication can modulate the duration of phenylephrine-induced effects on accommodation and pupil size.

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