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Mouse Models Of Helicobacter Infection And Gastric Pathologies
07:43

Mouse Models Of Helicobacter Infection And Gastric Pathologies

Published on: October 18, 2018

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Gastric microbiota dysbiosis and Helicobacter pylori infection

Ling Zhang1, Ming Zhao1, Xiangsheng Fu1

  • 1Department of Gastroenterology, Clinical Medical College, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.

Frontiers in Microbiology
|April 17, 2023
PubMed

Insights

Helicobacter pylori (H. pylori) infection eradication is difficult due to antibiotic resistance. Modulating the gastric microecology with probiotics or microbiota transplantation may offer new strategies for H. pylori treatment.

Area of Science:

  • Gastroenterology and Microbiology
  • Focuses on the complex interplay within the stomach's microbial ecosystem and its impact on gastric health.

Background:

  • Helicobacter pylori (H. pylori) infection is a primary cause of gastric disease.
  • Increasing antibiotic resistance complicates H. pylori eradication efforts.
  • The stomach harbors a unique, unsterile microecology with diverse microbial interactions.

Purpose of the Study:

  • To review the current understanding of gastric microecology and its role in gastric diseases.
  • To explore the relationship between H. pylori and other gastric microorganisms (bacteria, fungi, viruses).
  • To assess the potential of gastric microecology modulation for improving H. pylori eradication.

Main Methods:

  • Literature review of studies on gastric microecology, H. pylori, and related diseases.
  • Analysis of microbial interactions within the stomach niche.
  • Summary of modulation strategies including probiotics, prebiotics, postbiotics, synbiotics, and microbiota transplantation.

Main Results:

  • Gastric microecology significantly influences microbial fitness, population dynamics, and functional capacities.
  • Imbalances in gastric microecology are linked to various gastric diseases.
  • Non-H. pylori microbes, fungi, and viruses interact with H. pylori, affecting infection outcomes.

Conclusions:

  • Gastric microecology plays a crucial role in the pathogenesis and persistence of H. pylori infections.
  • Modulating the gastric microbiota presents a promising avenue for novel H. pylori eradication therapies.
  • Strategies like probiotics and microbiota transplantation warrant further investigation for clinical application.
Keywords:
H. pylori eradicationbacterial interactiongastric diseasesgastric microecologymicrobiota transplant

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