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A review of penicillin binding protein and group A Streptococcus with reduced-β-lactam susceptibility

Dingle Yu1, Danchun Guo1, Yuejie Zheng1

  • 1Shenzhen Children's Hospital, Shenzhen, China.

Frontiers in Cellular and Infection Microbiology
|April 17, 2023
PubMed

Insights

Antimicrobial resistance is a global health threat. This review examines penicillin-binding proteins in Group A Streptococcus (GAS) and their unusual susceptibility to beta-lactam antibiotics, highlighting potential resistance mechanisms.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Antimicrobial resistance (AMR) poses a significant global public health risk.
  • Group A Streptococcus (GAS) infections are prevalent worldwide, with beta-lactam antibiotics remaining the primary treatment.
  • A unique characteristic of beta-hemolytic streptococci is their sustained susceptibility to beta-lactams, a mechanism not fully understood.

Purpose of the Study:

  • To review current literature on GAS penicillin-binding proteins (PBPs) and their link to beta-lactam susceptibility.
  • To investigate the relationship between specific PBPs and beta-lactam resistance in GAS.
  • To raise awareness regarding the potential emergence of GAS strains with reduced susceptibility to beta-lactams.

Main Methods:

  • Literature review of published studies.
  • Analysis of data concerning GAS penicillin-binding proteins.
  • Examination of findings related to beta-lactam susceptibility in GAS.

Main Results:

  • Recent research implicates the penicillin-binding protein 2X (pbp2x) gene in reduced beta-lactam susceptibility in GAS.
  • The exact mechanisms driving beta-hemolytic streptococci's persistent susceptibility to beta-lactams require further elucidation.

Conclusions:

  • Understanding the role of PBPs, particularly pbp2x, is crucial for monitoring GAS beta-lactam susceptibility.
  • Continued vigilance is necessary to detect and address the potential rise of beta-lactam-resistant GAS strains.
Keywords:
Pbp2xPenicillin binding proteinStreptococcus pyogenesantibiotic resistancegroup A Streptococcus (GAS)reduced-penicillin susceptibilityβ-lactam

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