The standards of reporting randomized trials in pets (PetSORT): Methods and development processes.

Area of Science:

• Veterinary clinical trial methodology
• Scientific reporting standards
• Animal health research

Background:

• Reporting of clinical trials in pet populations is suboptimal, hindering assessment of trial reliability and validity.
• Inadequate reporting limits the inclusion of veterinary trials in evidence synthesis.
• There is a need for specific guidelines tailored to trials involving client- and shelter-owned dogs and cats.

Purpose of the Study:

• To develop a reporting guideline for parallel group and crossover trials in client- and shelter-owned dog and cat populations.
• To address the unique features and reporting requirements of veterinary clinical trials.
• To enhance the quality and consistency of reporting in veterinary research.

Main Methods:

• A consensus-based approach was used, involving 56 international experts.
• A draft checklist was developed based on the CONSORT statement and its extensions.
• The checklist items were iteratively modified and refined through virtual expert consensus until over 85% agreement was reached.

Main Results:

• The final PetSORT checklist comprises 25 main items with sub-items.
• Most items are adapted from existing CONSORT guidelines.
• A novel sub-item concerning euthanasia was created specifically for this guideline.

Conclusions:

• The development process utilized a novel virtual format, differing from traditional guideline development.
• The PetSORT statement is expected to significantly improve the reporting of veterinary clinical trials involving dogs and cats.
• Enhanced reporting will bolster the reliability and utility of veterinary research for evidence-based practice.