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Updated: Aug 2, 2025

Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Role of the PLASMIC Score in the Management of Thrombotic Thrombocytopenic Purpura
Abhinav Vyas1, Sangeetha Isaac1, Dania Kaur1
1Department of Internal Medicine, North Alabama Medical Center, Florence, USA.
Abstract:
We report the case of a middle-aged male presenting with fatigue and abdominal pain. Prompt investigations demonstrated microangiopathic hemolytic anemia and thrombocytopenia on a peripheral blood smear. Thrombotic thrombocytopenic purpura was suspected based on the PLASMIC score. The patient significantly improved with therapeutic plasma exchange and prednisone within the next few days. The disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13 levels reduction is a definitive hallmark leading to microvascular thrombosis. However, some medical centers in the United States do not promptly have quick allowance to the levels. Hence, the PLASMIC score becomes imminent in initiating immediate management and preventing life-threatening complications.
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