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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
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Diseases of the Liver and Gallbladder01:26

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Related Experiment Video

Updated: Aug 2, 2025

Application of Robot-assisted Pancreaticobiliary Junction Resection in Benign Duodenal Tumors
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Dubin-Johnson Syndrome: A Case Report.

Abdul Hannan Siddiqui1, Muhammad R Alsabe2, Zuha Tehseen3

  • 1Internal Medicine, University Hospital Derby and Burton, Derby, GBR.

Cureus
|April 17, 2023
PubMed
Summary

Dubin-Johnson syndrome (DJS) is a rare genetic disorder affecting bilirubin transport. This case highlights a teenage male with recurrent jaundice, emphasizing conservative management and a positive prognosis for DJS patients.

Keywords:
#conjugated hyperbilirubinemia#hyperbilirubinemia#liver#liver abnormalitiesdjsdubin jhonson syndromeliver histopathology

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Area of Science:

  • Genetics and Molecular Biology
  • Hepatology
  • Rare Diseases

Background:

  • Dubin-Johnson syndrome (DJS) is an autosomal recessive genetic disorder.
  • Caused by mutations in the multidrug resistance-associated protein 2 (MRP2) gene, affecting bilirubin transport.
  • Characterized by conjugated hyperbilirubinemia and recurrent jaundice.

Observation:

  • Presents a rare case of a teenage male with a history of jaundice since birth and abdominal pain.
  • The patient had a family history suggestive of a hereditary condition.
  • Clinical presentation included recurrent jaundice, a hallmark of DJS.

Findings:

  • Diagnostic evaluation confirmed Dubin-Johnson syndrome.
  • The patient's condition was managed conservatively.
  • Follow-up indicated a positive prognosis with conservative treatment.

Implications:

  • Highlights the importance of recognizing and diagnosing rare genetic liver diseases like DJS.
  • Underscores that DJS patients often have a normal life expectancy with appropriate management.
  • Emphasizes that conservative management is typically sufficient for Dubin-Johnson syndrome, preventing misdiagnosis and ensuring proper care.