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Prevalence of High Aldosterone-Renin Ratio in Patients With Hypertension in Basrah

Zeid Zwain1, Hussein A Nwayyir2, Haider A Alidrisi3

  • 1Diabetes and Endocrinology, Faiha Specialized Diabetes, Endocrine and Metabolism Center (FDEMC) University of Basrah, Basrah, IRQ.

Cureus
|April 17, 2023
PubMed

Insights

A significant 26% of Iraqi hypertensive patients screened showed an elevated aldosterone-renin ratio (ARR), a key indicator for primary aldosteronism. Further research with larger cohorts is recommended to confirm these findings in hypertension screening.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Clinical Diagnostics

Background:

  • The aldosterone-renin ratio (ARR) is a critical screening tool for primary aldosteronism, a common cause of secondary hypertension.
  • Identifying primary aldosteronism is crucial for effective hypertension management and reducing cardiovascular risk.

Purpose of the Study:

  • To determine the prevalence of elevated ARR in hypertensive patients within Iraq.
  • To assess the utility of ARR as a screening marker in a specific patient population.

Main Methods:

  • A retrospective study analyzed data from 150 hypertensive patients at the Faiha Specialized Diabetes, Endocrine and Metabolism Center (FDEMC) in Basrah.
  • An elevated ARR was defined as a ratio equal to or greater than 5.7.
  • Patient records were screened for endocrine causes of hypertension between February 2020 and November 2021.

Main Results:

  • Out of 150 patients, 39 (26%) exhibited an elevated ARR.
  • No statistically significant associations were found between elevated ARR and demographic factors (age, gender, BMI), hypertension duration, blood pressure levels, pulse rate, or comorbidities like diabetes mellitus and dyslipidemia.

Conclusions:

  • A high frequency (26%) of elevated ARR was observed in the studied hypertensive cohort.
  • The findings suggest a notable prevalence of potential primary aldosteronism among Iraqi hypertensive patients.
  • Larger-scale studies are warranted to validate these results and explore clinical implications.
Abstract

Keywords:
aldosterone-renin ratioaldosteronismbasrahhypertensioniraq

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