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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
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Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Colopathy Associated with Pentosan Polysulfate Use.

Emily H Jung, Wei Zheng, Ryan J Weiss

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    |April 17, 2023
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    Summary
    This summary is machine-generated.

    Pentosan polysulfate (PPS) use is strongly linked to inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). This study identifies a novel drug-associated colopathy with potential for dysplasia, highlighting the need for awareness.

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    Area of Science:

    • Gastroenterology
    • Pharmacology
    • Drug Safety

    Background:

    • Pentosan polysulfate (PPS) is used for interstitial cystitis.
    • A potential association between PPS and gastrointestinal disorders warrants investigation.

    Approach:

    • A two-part study investigated the link between PPS use and inflammatory bowel disease (IBD) and/or irritable bowel syndrome (IBS).
    • Methods included a cohort study of PPS users and a cross-sectional study of patients with interstitial cystitis.
    • Statistical analysis, including multivariate logistic regression, quantified the drug-disease association.

    Key Points:

    • In a cohort of 13 participants, 84.6% developed IBD/IBS symptoms after PPS initiation.
    • Histopathology revealed abnormal colonic mucosa in all reviewed cases, with improvement after PPS cessation.
    • PPS use was a significant predictor of IBD and composite IBD+IBS outcomes in 219 patients.

    Conclusions:

    • A strong association exists between pentosan polysulfate (PPS) use and diagnoses of IBD and/or IBS.
    • Findings suggest a novel drug-associated colopathy, with some cases progressing to dysplasia requiring colectomy.