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Updated: Aug 2, 2025
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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
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Multiple rotavirus species encode fusion-associated small transmembrane (FAST) proteins with cell type-specific
Vanesa Veletanlic1, Kylie Sartalamacchia1, Julia R Diller1
1Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Biorxiv : the Preprint Server for Biology
|April 17, 2023
Summary
Fusion-associated small transmembrane (FAST) proteins from rotavirus species B, G, and I induce cell fusion, primarily in primate cells. The N-terminal and transmembrane domains of these viral proteins dictate cell-type specificity for syncytia formation.
Area of Science:
- Virology
- Cell Biology
- Molecular Biology
Background:
- Fusion-associated small transmembrane (FAST) proteins are viral proteins mediating cell-cell fusion and syncytia formation.
- Human rotavirus species B NSP1-1 protein induces syncytia in primate cells but not rodent cells.
- The host and cell-type specificity of rotavirus FAST protein fusion activity is not well understood.
Conclusions:
- Rotavirus species B, G, and I NSP1-1 proteins function as FAST proteins.
- The N-terminal domain plays a crucial role in specifying the cell types where syncytia formation occurs.
- Further research is needed to clarify the exact species and cell type criteria governing rotavirus FAST protein fusion activity.
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