Related Experiment Video
Updated: Aug 2, 2025
08:08
Quantification of Breast Cancer Cell Invasiveness Using a Three-dimensional 3D Model
Published on: June 11, 2014
15.9K
Aged Breast Matrix Bound Vesicles Promote Breast Cancer Invasiveness
Biorxiv : the Preprint Server for Biology
|April 17, 2023
Summary
Aging breast tissue contains matrix-bound vesicles (MBVs) that promote cancer. These MBVs, altered with age, increase breast cancer cell motility and invasion, highlighting their role in tumor progression.
Area of Science:
- Biomedical Science
- Cancer Biology
- Aging Research
Background:
- Aging is a significant risk factor for breast cancer.
- The aging breast tissue microenvironment, particularly the extracellular matrix (ECM), remains understudied.
- Cellular alterations in aging are known, but changes in the ECM's regulatory components are less understood.
Conclusions:
- MBVs play a regulatory role in the tissue microenvironment.
- MBV composition shifts with age towards promoting cancer.
- Understanding MBV cargo and effects is crucial for comprehending breast cancer progression and metastasis.
Related Concept Videos
02:30Metastasis
5.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K
01:35Cancer Cell Migration through Invadopodia
2.3K
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
2.3K