Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A pre-induction test dose for suxamethonium.

J Carnie

    Anaesthesia
    |April 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    A novel test dose of suxamethonium can identify patients with abnormal plasma cholinesterase, preventing potential adverse reactions to muscle relaxants during anesthesia. This method detects sensitivity before a full dose is given.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Low mannose-binding lectin complement activation function is associated with predisposition to Legionnaires' disease.

    Clinical and experimental immunology·2007
    Same author

    Patient feedback on the anaesthetist's performance during the pre-operative visit.

    Anaesthesia·2002
    Same author

    Prediction by computerised tomography of distance from skin to epidural space during thoracic epidural insertion.

    Anaesthesia·2002
    Same author

    Laboratory enhanced surveillance for meningococcal disease in Victoria.

    Journal of paediatrics and child health·2002
    Same author

    Tuberculosis notifications in Australia, 1999.

    Communicable diseases intelligence quarterly report·2002
    Same author

    The impact of diagnosis by legionella urinary antigen test on the epidemiology and outcomes of Legionnaires' disease.

    Epidemiology and infection·2001

    Area of Science:

    • Anesthesiology
    • Pharmacology
    • Clinical Chemistry

    Background:

    • Suxamethonium is a common muscle relaxant used in anesthesia.
    • Individuals with abnormal plasma cholinesterase may experience prolonged paralysis after suxamethonium administration.
    • A reliable method to identify sensitive individuals pre-induction is needed.

    Purpose of the Study:

    • To evaluate suxamethonium's effects as a test dose to determine patient sensitivity.
    • To establish a protocol for identifying individuals with reduced suxamethonium hydrolysis before anesthesia.

    Main Methods:

    • A two-part experimental and clinical study was performed.
    • A low dose of suxamethonium (1-20 µg/kg) was administered as a test dose.
    • Clinical features and dose response were observed in individuals with normal and abnormal plasma cholinesterase.

    Related Experiment Videos

    Main Results:

    • Suxamethonium administration produced distinct signs of extraocular muscle contraction and paresis, including eye and eyelid heaviness.
    • Individuals with abnormal plasma cholinesterase showed heightened sensitivity to low suxamethonium doses.
    • Patients with normal and abnormal enzyme levels were clearly distinguishable based on their response.

    Conclusions:

    • A pre-induction test dose of suxamethonium can effectively identify individuals with reduced ability to hydrolyze the drug.
    • This protocol allows for the determination of suxamethonium sensitivity prior to administering a full intubation dose.
    • The observed clinical features provide a basis for a reliable sensitivity test.