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Study of blood rheological parameters and NO in coronary artery disease patients with and without collaterals

Maia Chigogidze1, Maia Mantskava2,3, Tamar Sanikidze4

  • 1Faculty of Medicine, Ivane Javakhishvili Tbilisi State University. Tbilisi, Georgia.

Clinical Hemorheology and Microcirculation
|April 17, 2023
PubMed

Insights

In coronary artery disease (CAD), reduced nitric oxide (NO) and increased erythrocyte aggregation impair blood flow and collateral development. Lower NO levels correlate with fewer developed collaterals, impacting angiogenesis.

Area of Science:

  • Cardiovascular Medicine
  • Rheology
  • Molecular Biology

Background:

  • Coronary artery disease (CAD) involves impaired blood flow to the myocardium.
  • Coronary collateral circulation offers an alternative pathway for blood supply in ischemic areas.
  • Understanding factors influencing collateral development is crucial for managing CAD.

Purpose of the Study:

  • To investigate blood rheological parameters and nitric oxide (NO) levels in CAD patients.
  • To correlate rheological factors and NO content with the degree of collateral development.
  • To explore the influence of blood fluidity on collateral angiogenesis in CAD.

Main Methods:

  • Study included patients with stable CAD undergoing coronary angiography and a control group.
  • Assessed blood rheology: plasma viscosity, erythrocyte aggregability, and deformability.
  • Measured stable metabolic end products of nitric oxide (NOx).

Main Results:

  • CAD patients exhibited increased erythrocyte aggregation and decreased NO levels compared to controls.
  • A significant inverse correlation was observed between NO content and the number of developed collaterals.
  • Lower NO levels were associated with less developed collateral circulation.

Conclusions:

  • Erythrocyte aggregation and endothelial nitric oxide (NO) play roles in regulating angiogenesis in CAD.
  • These factors may be involved in direct and feedback mechanisms of collateral development.
  • Findings highlight the importance of rheological properties and NO in CAD pathophysiology.
Abstract

Keywords:
Rheologyblood flowcollaterals

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