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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Preclinical Development: Overview01:28

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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A View on Drug Development for Cancer Prevention.

Andrew R Reynolds1, Michele Moschetta1, Alula R Yohannes2

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Developing new medicines for cancer prevention is crucial. This review outlines key strategies to accelerate the availability of cancer preventive drugs, addressing unmet needs and improving patient identification for better outcomes.

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Area of Science:

  • Oncology
  • Pharmacology
  • Public Health

Background:

  • Limited number of approved agents for cancer prevention despite significant public health benefits.
  • Recent advances in early detection and treatment modalities necessitate a re-evaluation of cancer prevention drug development.

Approach:

  • Reviewing progress in the development of medicines for cancer prevention.
  • Outlining key concepts to enable and accelerate future drug development.

Key Points:

  • Unmet clinical need in cancer prevention.
  • Improved patient identification and risk stratification.
  • Pharmacological interventions and optimized clinical trial designs.
  • Consideration of healthcare policy to support drug development.

Conclusions:

  • Addressing the outlined key themes can significantly increase the number of available medicines for cancer prevention.
  • A multi-faceted approach integrating scientific, clinical, and policy strategies is essential for advancing cancer prevention drug development.