Achieving the Goals of the Cancer Moonshot Requires Progress against All Cancers

Monica M Bertagnolli1, Danielle Carnival2, Elizabeth M Jaffee3

  • 1National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

Cancer Discovery
|April 17, 2023
PubMed
Abstract

Insights

The Cancer Moonshot aims to cut cancer mortality by 50% in 25 years. Achieving this ambitious goal requires significant advancements across research, healthcare, and public health initiatives.

Area of Science:

  • Oncology
  • Public Health Policy
  • Cancer Research

Background:

  • The Cancer Moonshot initiative, launched in February 2022, set a target to reduce age-adjusted cancer mortality by at least 50% within 25 years.
  • This ambitious goal aligns with national efforts to combat cancer and improve patient outcomes through scientific and policy-driven strategies.

Discussion:

  • While recent progress indicates the goal is attainable, sustained commitment is crucial.
  • Success hinges on comprehensive advancements spanning basic science, clinical and translational research, healthcare delivery systems, and public health interventions.

Key Insights:

  • The 50% reduction target for cancer mortality is a significant public health objective.
  • Interdisciplinary collaboration is essential for translating research findings into clinical practice and population-level impact.
  • Progress in cancer research and treatment is critical to meeting the Cancer Moonshot's objectives.

Outlook:

  • Continued investment in basic and translational cancer research is vital.
  • Enhancing healthcare delivery and public health programs will accelerate progress towards the mortality reduction goal.
  • The initiative underscores the importance of a multi-faceted approach to cancer control.

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.2K
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
456
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
406