Introduction to Pharmaceutical Co-amorphous Systems Using a Green Co-milling Technique.
Joana F C Silva1, Mário T S Rosado1, Teresa M R Maria1
1CQC-IMS, Dep. de Química, Universidade de Coimbra, Rua Larga, Coimbra 3004-535, Portugal.
Journal of Chemical Education
|April 17, 2023
Summary
This study introduces co-amorphous systems using green mechanochemistry for advanced chemistry students. The naproxen-cimetidine co-amorphous system (NPX-CIM) is explored, highlighting solid-state characterization and pharmaceutical relevance.
Area of Science:
- Materials Science
- Green Chemistry
- Pharmaceutical Science
Background:
- Co-amorphous systems offer improved drug properties.
- Mechanochemistry provides a solvent-free, environmentally friendly synthesis route.
- Understanding solid-state properties is crucial for pharmaceutical development.
Purpose of the Study:
- To introduce co-amorphous systems and medicinal mechanochemistry.
- To provide an integrated laboratory experiment for advanced chemistry students.
- To demonstrate the synthesis and characterization of a dual-drug co-amorphous system.
Main Methods:
- Solvent-free mechanochemical synthesis of naproxen-cimetidine (NPX-CIM).
- Solid-state characterization using X-ray powder diffraction (XRPD).
- Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC).
Main Results:
- Successful synthesis of the NPX-CIM co-amorphous system.
- Demonstration of key solid-state characterization techniques.
- Insight into the properties of disordered pharmaceutical materials.
Conclusions:
- The experiment effectively integrates medicinal mechanochemistry and solid-state analysis.
- It is suitable for master's level courses in instrumental analysis, solid-state chemistry, or green chemistry.
- The lab session emphasizes the importance of different solid forms in pharmaceutics.
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