Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EEG responses to auditory stimuli are less context-dependent in preschoolers with autism spectrum disorder compared to typical development.

medRxiv : the preprint server for health sciences·2026
Same author

The neurovascular impulse response function differentially reflects intrinsic neuromodulation across cortical regions.

Nature neuroscience·2026
Same author

Oddball Evoked Deviant Responses Reflect Complex Context-Dependent Expectations in Mouse V1.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025
Same author

Structured experience shapes strategy learning and neural dynamics in the medial entorhinal cortex.

bioRxiv : the preprint server for biology·2025
Same author

Neurovascular Impulse Response Function (IRF) during spontaneous activity differentially reflects intrinsic neuromodulation across cortical regions.

bioRxiv : the preprint server for biology·2025
Same author

Sleep is necessary for experience-dependent sequence plasticity in mouse primary visual cortex.

Sleep·2024

Related Experiment Video

Updated: Aug 2, 2025

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex
08:42

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex

Published on: February 8, 2020

10.1K

Sex and estrous cycle affect experience-dependent plasticity in mouse primary visual cortex.

Rachel W Schecter1, Cambria M Jensen1, Jeffrey P Gavornik1

  • 1Center for Systems Neuroscience, Biology Department, Boston University, Boston, MA, United States of America.

Plos One
|April 17, 2023
PubMed
Summary

Sex and estrous stage do not affect baseline visual acuity in mice. However, both factors significantly influence experience-dependent cortical plasticity in the primary visual cortex (V1).

More Related Videos

A Highly Reproducible and Straightforward Method to Perform In Vivo Ocular Enucleation in the Mouse after Eye Opening
05:29

A Highly Reproducible and Straightforward Method to Perform In Vivo Ocular Enucleation in the Mouse after Eye Opening

Published on: October 6, 2014

23.6K
Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

1.5K

Related Experiment Videos

Last Updated: Aug 2, 2025

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex
08:42

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex

Published on: February 8, 2020

10.1K
A Highly Reproducible and Straightforward Method to Perform In Vivo Ocular Enucleation in the Mouse after Eye Opening
05:29

A Highly Reproducible and Straightforward Method to Perform In Vivo Ocular Enucleation in the Mouse after Eye Opening

Published on: October 6, 2014

23.6K
Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

1.5K

Area of Science:

  • Neuroscience
  • Physiology

Background:

  • Sex hormones influence brain function, but sex-dependent differences are not well understood.
  • Historically, neuroscience research has predominantly used male animals, overlooking sex as a biological variable.
  • Recent directives emphasize including sex as a factor in research to address sex-based biological differences.

Purpose of the Study:

  • To investigate sex- and estrous cycle-dependent differences in visual processing and cortical plasticity.
  • To characterize baseline visual function and experience-dependent plasticity in the primary visual cortex (V1) of male and female mice.
  • To determine if sex and estrous stage modulate visual cortex plasticity.

Main Methods:

  • In vivo electrophysiological recordings in the primary visual cortex (V1) of male and female mice.
  • Assessment of baseline visual acuity.
  • Measurement of two distinct forms of experience-dependent cortical plasticity.
  • Analysis of data considering sex and estrous cycle stage.

Main Results:

  • No statistically significant effect of sex or estrous stage on baseline visual acuity measurements.
  • Both sex and estrous stage significantly modulate two distinct forms of experience-dependent cortical plasticity in V1.
  • Variability in plasticity due to sex and estrous stage can be managed with appropriate normalization techniques.

Conclusions:

  • Sex and estrous stage are critical factors influencing experience-dependent cortical plasticity in the mammalian visual cortex.
  • The primary visual cortex (V1) exhibits plasticity that is modulated by sex hormones and estrous cycle.
  • These findings support using V1 plasticity to study the mechanistic effects of sex hormones on experience-dependent plasticity.