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Paraneoplastic digital thrombosis: a case report.

G Albin, A C Lapeyre, R L Click

    Angiology
    |March 1, 1986
    PubMed
    Summary
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    Digital ischemia, a rare paraneoplastic syndrome, was the sole indicator of adenocarcinoma in a 71-year-old man. Surgical intervention provided significant symptom relief, though the exact cause remains unknown.

    Area of Science:

    • Oncology
    • Vascular Surgery
    • Medical Syndromes

    Background:

    • Paraneoplastic syndromes are rare manifestations of cancer.
    • Digital ischemia can be an uncommon paraneoplastic presentation.
    • Adenocarcinoma can present with unusual paraneoplastic symptoms.

    Observation:

    • A 71-year-old male presented with persistent digital ischemia.
    • Digital ischemia was the only presenting sign of an underlying adenocarcinoma.
    • The patient's symptoms were unresponsive to initial treatments.

    Findings:

    • Bilateral dorsal sympathectomies resulted in a dramatic improvement of digital ischemia.
    • Extensive investigation failed to identify the specific mechanism causing the ischemia.
    • The paraneoplastic digital ischemia was presumed to be caused by unknown neurohumoral factors from the tumor.

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    Implications:

    • This case highlights the importance of considering paraneoplastic syndromes in unexplained peripheral ischemia.
    • Surgical sympathectomy can be an effective treatment for paraneoplastic digital ischemia.
    • Further research is needed to elucidate the neurohumoral mechanisms involved in paraneoplastic digital ischemia.