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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

Updated: Aug 2, 2025

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[Acupuncture for glaucoma-induced optic atrophy: a randomized controlled trial].

Shui-Ling Chen1, Li-Qun Chu1, Fang-Fang Tao1

  • 1Department of Ophthalmology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China.

Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion
|April 17, 2023
PubMed
Summary

Acupuncture, combined with standard treatment, helps preserve vision and retinal nerve fiber layer thickness in glaucoma patients. This approach delays vision decline and thinning of the retinal nerve fiber layer.

Keywords:
acupunctureglaucomaoptic atrophyrandomized controlled trial (RCT)retinal nerve fiber layervision

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Area of Science:

  • Ophthalmology
  • Neurology
  • Integrative Medicine

Background:

  • Glaucoma-induced optic atrophy leads to progressive vision loss.
  • Current treatments aim to manage intraocular pressure but often fail to halt optic nerve damage.
  • There is a need for adjunctive therapies to protect the optic nerve.

Purpose of the Study:

  • To evaluate the clinical efficacy of acupuncture as an add-on therapy for glaucoma-induced optic atrophy.
  • To assess acupuncture's impact on visual acuity, visual field, and retinal nerve fiber layer thickness.

Main Methods:

  • A randomized controlled trial involving 70 patients with glaucoma-induced optic atrophy.
  • The observation group received acupuncture plus standard Western medicine; the control group received standard Western medicine alone.
  • Key outcome measures included best-corrected visual acuity (BCVA), intraocular pressure (IOP), visual field indices, and retinal nerve fiber layer (RNFL) thickness.

Main Results:

  • The acupuncture group showed a slower decline in BCVA compared to the control group during follow-up.
  • Mean RNFL thickness was significantly greater in the acupuncture group post-treatment and during follow-up.
  • No significant differences in IOP were observed between groups.

Conclusions:

  • Acupuncture, as an adjunct to Western medicine, can help preserve vision and RNFL thickness in patients with glaucoma-induced optic atrophy.
  • Acupuncture may offer a neuroprotective effect, delaying disease progression.
  • Further research is warranted to elucidate the mechanisms of action.