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Therapy-Induced Tumor Cell Senescence: Mechanisms and Circumvention

Maria A Zamkova1,2, Nadezhda A Persiyantseva3,2, Victor V Tatarskiy3

  • 1Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia. zamkovam@gmail.com.

Biochemistry. Biokhimiia
|April 17, 2023
PubMed

Insights

Tumor cells adapt to therapy by entering a senescence phenotype, becoming drug-resistant and generating aggressive offspring. Targeting transcriptional reprogramming offers a new strategy to prevent this unfavorable outcome.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cellular Senescence

Background:

  • Tumor cells exhibit plasticity, enabling evasion of chemotherapy and radiation.
  • Surviving cancer cells undergo metabolic adaptation via transcriptional reprogramming.
  • Therapy-induced senescence in tumor cells mirrors natural aging, leading to drug resistance.

Purpose of the Study:

  • To analyze the regulatory mechanisms of therapy-induced tumor cell senescence.
  • To review novel drug combinations for preventing this clinically unfavorable phenomenon.
  • To highlight the significance of transcriptional reprogramming in stress adaptation.

Main Methods:

  • Literature review of molecular regulation pathways in tumor cell plasticity.
  • Analysis of transcriptional reprogramming in surviving cancer cells.
  • Examination of senescence phenotype characteristics and implications.

Main Results:

  • Therapy-induced senescence confers resistance to cytotoxic drugs.
  • Senescent tumor cells can produce more aggressive progeny.
  • Transcriptional reprogramming is a key adaptation mechanism for stress survival.

Conclusions:

  • Therapy-induced tumor cell senescence is a critical challenge in cancer treatment.
  • Understanding senescence mechanisms is vital for developing effective therapies.
  • Pharmacological targeting of transcriptional reprogramming holds promise for overcoming treatment resistance.
Keywords:
antitumor treatmentcytotoxicitygene transcriptionintracellular signalstherapy-induced cell senescencetransformed cells

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