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Updated: Aug 2, 2025

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
One-Pot Synthesis of Diverse 1,4-[60]Fullerephenols via Three-Component Umpolung Cascade Coupling of Phenols, C60 ,
Jun-Xiang Zhang1, Yuan-Ze Wu1, Dong-Mei Chen1
1Anhui Province Key Laboratory of Structure and Functional Regulation of Hybrid Materials, College of Chemistry & Chemical Engineering, Department of Chemistry, Anhui University, 230601, Hefei, Anhui, P. R. China.
Abstract:
A three-component umpolung cascade coupling reaction of phenols, C60 , and different nucleophiles which includes H2 O, alcohols, triphenylamines and carbazoles was developed. Furthermore, one-pot 1,4-bisphenol coupling on C60 has been realized by this method. This practical protocol features high chemo- and regioselectivity, wide substrate range, easy operation and low cost, thus providing a robust method for the one-pot synthesis of various unsymmetrical 1,4-[60]fullerephenols.
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