Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Spermatogenesis01:41

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety and Tolerability of Thrombin Inhibition in Scleroderma-Associated Interstitial Lung Disease.

ACR open rheumatology·2019
Same author

Response to Letter to the Editor: Do we have to redefine lameness in the era of quantitative gait analysis.

Equine veterinary journal·2018
Same author

Developmental Ethanol-Induced Sleep Fragmentation, Behavioral Hyperactivity, Cognitive Impairment and Parvalbumin Cell Loss are Prevented by Lithium Co-treatment.

Neuroscience·2017
Same author

Shaping polymersomes into predictable morphologies via out-of-equilibrium self-assembly.

Nature communications·2016
Same author

Developmental ethanol exposure-induced sleep fragmentation predicts adult cognitive impairment.

Neuroscience·2016
Same author

Med Wise: A theory-based program to improve older adults' communication with pharmacists about their medicines.

Research in social & administrative pharmacy : RSAP·2015
Same journal

Correction to I.M. Matters News: Sleep medicine for seniors.

Annals of internal medicine·2026
Same journal

Adverse Events After Same-Day COVID-19 and Influenza Vaccination Versus Influenza Vaccination Alone : A Target Trial Emulation.

Annals of internal medicine·2026
Same journal

Leveraging Real-World Evidence to Inform Regulatory, Clinical, and Coverage Decisions Related to Glucagon-Like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Annals of internal medicine·2026
Same journal

Methodological Approaches to Real-World Evidence Generation for Glucagon-like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Annals of internal medicine·2026
Same journal

Weekly and Biweekly Treatment With Bofanglutide Versus Semaglutide in Chinese Patients With Type 2 Diabetes : A Phase 2b Randomized Clinical Trial.

Annals of internal medicine·2026
Same journal

Grappling with GLP-1 prescribing.

Annals of internal medicine·2026
See all related articles

Related Experiment Video

Updated: Jun 26, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Impotence in scleroderma.

N S Nowlin, J E Brick, D J Weaver

    Annals of Internal Medicine
    |June 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Scleroderma patients frequently experience impotence, unlike those with rheumatoid arthritis. Vascular issues, particularly small vessel disease, appear to be the primary cause of impotence in scleroderma.

    More Related Videos

    Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease
    02:21

    Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease

    Published on: March 15, 2024

    Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
    04:22

    Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

    Published on: May 30, 2025

    Related Experiment Videos

    Last Updated: Jun 26, 2026

    Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
    04:44

    Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

    Published on: June 16, 2020

    Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease
    02:21

    Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease

    Published on: March 15, 2024

    Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
    04:22

    Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

    Published on: May 30, 2025

    Area of Science:

    • Urology
    • Rheumatology
    • Vascular Medicine

    Background:

    • Erectile dysfunction is a common concern in systemic diseases.
    • Scleroderma and rheumatoid arthritis are autoimmune conditions with distinct pathologies.

    Purpose of the Study:

    • To investigate the hormonal, neurologic, and vascular factors contributing to impotence in men with scleroderma.
    • To compare these factors with those in age-matched men with rheumatoid arthritis.

    Main Methods:

    • Evaluated 10 men with scleroderma and 10 with rheumatoid arthritis.
    • Assessed hormonal profiles (serum testosterone, FSH, LH, prolactin, estradiol, thyroxine, TSH).
    • Conducted physical examinations for neurologic causes and measured penile blood pressures.

    Main Results:

    • Six out of 10 scleroderma patients reported impotence; none of the rheumatoid arthritis patients did.
    • Hormonal and neurologic evaluations did not reveal a cause for impotence.
    • Penile blood pressures were abnormal in 4 impotent scleroderma patients, suggesting vascular compromise.
    • Large vessel disease was identified in 2 impotent patients; small vessel disease was implicated in the remaining 4.

    Conclusions:

    • Impotence is significantly more prevalent in men with scleroderma than rheumatoid arthritis.
    • Vascular factors, especially small vessel disease affecting penile arteries, are the likely cause of impotence in scleroderma.
    • Hormonal and neurologic factors do not appear to be primary contributors to impotence in this scleroderma cohort.