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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Updated: Aug 2, 2025

Author Spotlight: Advancements in Nanoparticle Technology for Drug Delivery and Immunotherapy

Author Spotlight: Advancements in Nanoparticle Technology for Drug Delivery and Immunotherapy

Published on: November 10, 2023

DNA-based Nanomaterials in the Immunotherapy.

Hongxiao Huang¹, Shaojingya Gao¹, Xiaoxiao Cai¹

¹State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Current Drug Metabolism

|April 18, 2023

Summary

DNA-based nanomaterials, developed using nanotechnology, show great promise for immunotherapy. Their unique properties make them effective for treating diseases like cancer and autoimmune disorders.

Keywords:

DNA-based nanomaterials Nanotechnology autoimmune diseases drug delivery systems immunotherapy inflammatory diseases tumor therapy

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Area of Science:

Nanotechnology
Biomaterials Science
Immunotherapy

Background:

Nucleic acids, particularly DNA, are fundamental genetic materials with vast biological application potential.
Nanotechnology has enabled the fabrication of advanced DNA-based nanomaterials with evolving structural complexity.
Research in DNA-based nanomaterials for biological applications, especially immunotherapy, is rapidly advancing.

Approach:

A comprehensive literature search was conducted on nanotechnology and immunotherapy research.
Current DNA-based nanomaterials in immunotherapy were analyzed for their advantages and disadvantages.
DNA-based nanomaterials were compared with traditional biomaterials used in immunotherapy.

Key Points:

DNA-based nanomaterials offer exceptional editability and biocompatibility.
They function as therapeutic particles influencing cellular behavior and as drug delivery systems.
Loading DNA-based nanomaterials with therapeutic agents significantly enhances treatment efficacy.

Conclusions:

DNA-based nanomaterials represent a promising class of materials for immunotherapy.
Their structural evolution and biological applications are crucial for treating various diseases.
Potential applications include the treatment of cancer, autoimmune diseases, and inflammatory conditions.