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Forward Genetic Approaches in Chlamydia trachomatis
09:03

Forward Genetic Approaches in Chlamydia trachomatis

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Prostatitis as initial manifestation of Chlamydia psittaci pneumonia diagnosed by metagenome next-generation

Mengjie Li1, Biao Wang1, Peng Liu1

  • 1Department of Respiratory and Critical Care Medicine, Cangzhou Fifth Hospital (People's Hospital of Qingxian), Cangzhou 062650, China.

Open Life Sciences
|April 18, 2023
PubMed

Insights

Chlamydia psittaci pneumonia, a zoonotic disease, is often missed. Metagenomic next-generation sequencing (mNGS) aided in diagnosing this rare infection presenting with atypical prostatitis symptoms, leading to effective doxycycline treatment.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pulmonology

Background:

  • Chlamydia psittaci (C. psittaci) causes a zoonotic pneumonia that is frequently underdiagnosed.
  • Metagenomic next-generation sequencing (mNGS) offers an unbiased approach for identifying novel or rare pathogens.

Observation:

  • A 46-year-old male presented with recurrent pneumonia and prostatitis despite empirical antibiotic treatment.
  • Patient history revealed contact with pigeons, prompting further investigation.
  • Chest CT scans indicated worsening pulmonary inflammation.

Findings:

  • Bronchoalveolar lavage fluid analysis using mNGS identified C. psittaci infection.
  • Doxycycline treatment rapidly resolved the patient's symptoms and pulmonary lesions.
  • The patient recovered fully within a month.

Implications:

  • C. psittaci pneumonia can manifest with atypical symptoms, including prostatitis.
  • mNGS is a valuable diagnostic tool for identifying challenging or unusual infectious agents like C. psittaci.
  • Early and accurate diagnosis improves patient outcomes for zoonotic lung infections.
Keywords:
Chlamydia psittacicase reportinitial manifestationmetagenomic next-generation sequencingpneumoniaprostatitis

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