Understanding renal phosphate handling: unfinished business
1Assistant Chief Medical Services, Co-Director NODES Program, Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, Division of Nephrology, University of Texas Southwestern Medical Center, Medical Services for Research, NODES Program, VA North Texas Healthcare Services, Dallas, Texas, USA.
Current Opinion in Nephrology and Hypertension
|April 18, 2023
Summary
Recent research reveals novel mechanisms in renal phosphate handling, linking phosphate transport to cell metabolism and identifying persistent transporter expression in chronic kidney disease for potential new therapies.
Area of Science:
- Nephrology
- Molecular Biology
- Physiology
Background:
- Renal phosphate handling is crucial for maintaining mineral homeostasis.
- Sodium-phosphate cotransporters play a key role in phosphate reabsorption.
- Dysregulation of phosphate handling is implicated in various kidney diseases.
Conclusions:
- Novel transporter mechanisms offer new therapeutic targets for phosphate homeostasis disorders.
- Phosphate transport regulates proximal tubule cell metabolism, impacting kidney function preservation.
- Persistent active renal phosphate transport in CKD challenges existing assumptions and suggests new therapeutic avenues for phosphate retention.
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