Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antitumor metallocenes: new developments and toxicologic features.

P Köpf-Maier, H Köpf

    Anticancer Research
    |March 1, 1986
    PubMed
    Summary

    New titanocene derivatives show significant antitumor activity against various cancers, including melanoma and human tumors. These compounds exhibit a distinct organ toxicity profile compared to platinum-based chemotherapy agents.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Erratum to: Differential diagnosis of gallbladder abnormalities : Ultrasound, computed tomography, and magnetic resonance imaging].

    Der Radiologe·2019
    Same author

    [Differential diagnosis of gallbladder abnormalities : Ultrasound, computed tomography, and magnetic resonance imaging].

    Der Radiologe·2019
    Same author

    Ultrasound-guided interventions at peripheral nerves: diagnostic and therapeutic indications.

    Ultraschall in der Medizin (Stuttgart, Germany : 1980)·2011
    Same author

    Diagnostic sonography of peripheral nerves: indications, examination techniques and pathological findings.

    Ultraschall in der Medizin (Stuttgart, Germany : 1980)·2011
    Same author

    About a case of acute caffeine poisoning.

    Medizinische Klinik·2010
    Same author

    Postinterventional volume dynamics following endovascular treatment of infrarenal aortic aneurysms.

    The Journal of cardiovascular surgery·2007

    Area of Science:

    • Organometallic chemistry
    • Cancer research
    • Pharmacology

    Background:

    • Metallocene derivatives, particularly titanocene compounds, are emerging as potential anticancer agents.
    • Initial studies focused on titanocene dihalides and bis(pseudohalides).
    • Expanding research includes titanocene complexes with carboxylate or aminothiophenolate ligands.

    Purpose of the Study:

    • To investigate the antiproliferative and antineoplastic efficacy of novel titanocene derivatives.
    • To evaluate the antitumor activity against a broader range of cancer models.
    • To compare the organ toxicity profile of titanocene dichloride with established platinum-based drugs.

    Main Methods:

    • Synthesis and characterization of new titanocene complexes.
    • In vitro antiproliferative assays against various cancer cell lines.
    • In vivo antitumor studies using tumor models (e.g., B16 melanoma, sarcoma 180, human tumors in athymic mice).
    • Organ toxicity assessments in animal models.

    Main Results:

    • Several titanocene derivatives, including dihalides, bis(pseudohalides), and complexes with carboxylate/aminothiophenolate ligands, demonstrated significant antiproliferative activity.
    • Antitumor efficacy was confirmed against Ehrlich ascites tumor, B16 melanoma, sarcoma 180, and human tumors xenografted to athymic mice.
    • Titanocene dichloride displayed an organ toxicity profile distinct from that of platinum-based cytostatic agents.

    Conclusions:

    • Titanocene derivatives represent a promising class of novel anticancer agents with broad-spectrum activity.
    • These compounds offer a potentially alternative therapeutic strategy with a different toxicity profile compared to platinum drugs.
    • Further research into titanocene-based chemotherapy is warranted to explore their full therapeutic potential.

    Related Experiment Videos