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Materials for Controlled Release of Local Anesthetics
Yang Li1, Gwen E Owens1, Daniel S Kohane1
1Department of Anesthesiology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.
Chemmedchem
|April 18, 2023
Summary
Controlled release systems offer prolonged local anesthesia, addressing the opioid crisis. Research explores various designs, from simple to advanced triggered delivery, enhancing pain management options.
Area of Science:
- Biomaterials Science
- Anesthesiology
- Drug Delivery Systems
Background:
- Prolonged local anesthesia is crucial for effective pain management.
- The opioid epidemic necessitates safer alternatives to systemic analgesics.
- Controlled release technologies are emerging for clinical application.
Purpose of the Study:
- To review design considerations for controlled release local anesthetic systems.
- To discuss material properties relevant to sustained drug delivery.
- To explore advanced delivery mechanisms including external stimuli triggers.
Main Methods:
- Literature review of controlled release systems for local anesthetics.
- Analysis of material properties impacting drug release kinetics.
- Categorization of delivery systems from simple to complex.
Main Results:
- Various controlled release strategies exist for local anesthetics.
- Material selection is critical for achieving desired release profiles.
- Covalent drug binding and externally triggered systems offer advanced control.
Conclusions:
- Controlled release systems are vital for extended local anesthesia.
- Technological advancements are enabling sophisticated drug delivery solutions.
- These systems hold promise for improved pain management and reduced opioid reliance.
Keywords:
Biocompatibilitycontrolled drug releaselocal anestheticsmicroparticles and nanoparticlesopioid sparingMore Related Videos
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