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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Current status and prospects of MOFs in controlled delivery of Pt anticancer drugs

Jinyi Chen1,2, Zhixin Zhang2, Jiaxin Ma2

  • 1The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, 523808, China. pangying@gdmu.edu.cn.

Dalton Transactions (Cambridge, England : 2003)
|April 18, 2023
PubMed

Insights

Platinum-based drugs show promise for overcoming cancer treatment resistance. Combining these drugs with metal-organic frameworks (MOFs) offers a novel therapeutic strategy for complex tumors.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Oncology

Background:

  • Cancer is a leading global cause of death, with complex tumor microenvironments posing significant therapeutic challenges.
  • Tumor resistance to conventional therapies remains a critical obstacle in cancer treatment.
  • Platinum-based drugs, as metal complexes, have demonstrated efficacy in overcoming tumor resistance.

Purpose of the Study:

  • To review the application of platinum-based drugs in cancer therapy.
  • To explore the synergistic anticancer properties of platinum and metal-organic frameworks (MOFs).
  • To discuss the future prospects of platinum-MOF composites in biomedical applications.

Main Methods:

  • Literature review of platinum-based anticancer drugs.
  • Analysis of metal-organic frameworks (MOFs) as drug delivery systems.
  • Evaluation of composite platinum-MOF materials for anticancer activity.

Main Results:

  • Platinum-based metal complexes are effective against tumor resistance.
  • Metal-organic frameworks (MOFs) offer high porosity and suitability for biomedical applications.
  • Composite platinum-MOF materials exhibit enhanced anticancer properties.

Conclusions:

  • Platinum-MOF composites represent a promising new direction for cancer therapy development.
  • Further research into these materials could lead to improved treatments for complex and resistant tumors.
  • This review provides a foundation for future investigations in the biomedical field.

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